Prostate Biopsy

Prostate biopsy is recommended when there is a suspicion of prostate cancer. It can be done in three different ways.

Traditional Transrectal Biopsy in office

MRI FUSION Transrectal Biopsy

Saturation Biopsy

The traditional way is done in the office with local anesthesia around the prostate. Transrectal ultrasound of the prostate uses sound waves to view the prostate. This allows the physician to measure the size of the prostate and determine where to take the needle biopsies

To perform the prostate biopsy, a thin needle will be passed through a channel in the ultrasound probe. During each tissue sampling, you will hear a snap as a small spring-loaded device takes a specimen. You may feel some pressure and slight discomfort.

To minimize the possibility of infection you will be given a prescription for an antibiotic to fill at your pharmacy that should be started one hour prior to the procedure. There is a 3% chance of developing a high fever in spite of oral antibiotics, this may be an indication of a septic infection and your antibiotic may need to be changed. Half of the patients that develop this may need to be admitted to the hospital for IV antibiotics. Please contact our office immediately if symptoms occur. While you may return to normal activities the following day, you may want to take it easy the day of the biopsy and avoid any strenuous activity for at least 48 hrs. Keep yourself well hydrated, drink plenty of fluids.

It is not unusual to have some bleeding after the biopsy. You may see some blood in your urine, stool and semen on and off for up to 6 weeks. If bleeding becomes heavy, you develop a fever or have difficulty urinating, please call the office

It generally takes over one and a half weeks to receive results. The doctor will discuss results at your two week follow up appointment. Results will not be given over the phone.

MRI FUSION Transrectal Biopsy – This is done similar to the traditional way except an MRI of the prostate is done first. The image is fused with a special ultrasound instrument and the biopsy is done using both images. This is done at a different location and frequently under general anesthesia.

Saturation Biopsy – This is done using a different approach. The needle biopsy is done through the perineal area, which is the skin area behind the scrotal sac. It also uses ultrasound for guidance and is done under general anesthesia. The major advantage of this approach is the infection rate is extremely low because the biopsy needle is not passed transrectal.


  • Use one Fleet enema two hours prior to your appointment.
  • Take your antibiotic 2 hours prior to the procedure.
  • There are no fasting requirements, however, we do recommend a light meal and to keep well hydrated the day of your biopsy.
  • Do not take aspirin, Advil, Motrin, ibuprofen or any blood-thinning medications 7 days prior to your procedure.
  • Check with your prescribing physician prior to discontinuing these medications.
  • You must have a driver to and from your appointment.